The isoflavone puerarin promotes generation of human iPSC‐derived pre‐oligodendrocytes and enhances endogenous remyelination in rodent models

再髓鞘化 葛根素 少突胶质细胞 髓鞘 内生 神经干细胞 小胶质细胞 多发性硬化 生物 祖细胞 神经科学 药理学 干细胞 细胞生物学 医学 免疫学 中枢神经系统 炎症 病理 生物化学 替代医学
作者
Hao Xu,Huiyuan Zhang,Nona Pop,Jennifer Hall,Ibrahim Shazlee,Moritz Wagner‐Tsukamoto,Zhiguo Chen,Yuchun Gu,Chao Zhao,Dan Ma
出处
期刊:Journal of Neurochemistry [Wiley]
标识
DOI:10.1111/jnc.16245
摘要

Abstract Puerarin, a natural isoflavone, is commonly used as a Chinese herbal medicine for the treatment of various cardiovascular and neurological disorders. It has been found to be neuroprotective via TrK‐PI3K/Akt pathway, which is associated with anti‐inflammatory and antioxidant effects. Myelin damage in diseases such as multiple sclerosis (MS) and ischemia induces activation of endogenous oligodendrocyte progenitor cells (OPC) and subsequent remyelination by newly formed oligodendrocytes. It has been shown that human‐induced pluripotent stem cells (hiPSC)‐derived OPCs promote remyelination when transplanted to the brains of disease models. Here, we ask whether and how puerarin is beneficial to the generation of hiPSC‐derived OPCs and oligodendrocytes, and to the endogenous remyelination in mouse demyelination model. Our results show that puerarin increases the proportion of O4+ pre‐oligodendrocytes differentiated from iPSC‐derived neural stem cells. In vitro, puerarin increases proliferation of rat OPCs and enhances mitochondrial activity. Treatment of puerarin at progenitor stage increases the yielding of differentiated oligodendrocytes. In rat organotypic brain slice culture, puerarin promotes both myelination and remyelination. In vivo, puerarin increases oligodendrocyte repopulation during remyelination in mouse spinal cord following lysolethicin‐induced demyelination. Our findings suggest that puerarin promotes oligodendrocyte lineage progression and myelin repair, with a potential to be developed into therapeutic agent for neurological diseases associated with myelin damage. image
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
华仔应助悲惨雪糕W采纳,获得10
3秒前
4秒前
丘比特应助jjjxxxmmm采纳,获得10
4秒前
4秒前
4秒前
明熙发布了新的文献求助30
5秒前
6秒前
大方的寻雪完成签到,获得积分10
6秒前
8秒前
景笑天发布了新的文献求助10
8秒前
gp_liu发布了新的文献求助10
9秒前
9秒前
南瓜难给小薛的求助进行了留言
9秒前
10秒前
彩色的无声完成签到,获得积分10
11秒前
12秒前
双皮奶发布了新的文献求助10
12秒前
13秒前
Orange应助Lsy采纳,获得10
13秒前
13秒前
13秒前
iyiyii发布了新的文献求助10
14秒前
Michelle发布了新的文献求助10
14秒前
15秒前
SamuelLiu完成签到,获得积分10
16秒前
17秒前
苏书白应助Annie采纳,获得10
17秒前
17秒前
17秒前
aaaaa完成签到,获得积分10
17秒前
18秒前
阿西吧发布了新的文献求助10
18秒前
完美世界应助上官尔芙采纳,获得10
19秒前
20秒前
20秒前
medxyy发布了新的文献求助20
21秒前
zgtmark完成签到,获得积分10
22秒前
23秒前
程大海发布了新的文献求助10
23秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi 400
Classics in Total Synthesis IV 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3149784
求助须知:如何正确求助?哪些是违规求助? 2800775
关于积分的说明 7841901
捐赠科研通 2458351
什么是DOI,文献DOI怎么找? 1308425
科研通“疑难数据库(出版商)”最低求助积分说明 628499
版权声明 601706