光敏剂
单线态氧
化学发光
光化学
光动力疗法
辐照
材料科学
草酸盐
肽
生物物理学
化学
氧气
有机化学
生物化学
物理
核物理学
生物
作者
Shasha Liu,Jinrong Yang,Jinwu Yan
标识
DOI:10.1021/acsami.4c06901
摘要
Oxidative degradation of the pathogenic amyloid-β-peptide (Aβ) aggregation is an effective and promising method to treat Alzheimer's disease under light irradiation. However, the limited penetration of external light sources into deep tissues has hindered the development of this treatment. Therefore, we have designed an unprecedented chemiluminescence-initiated photodynamic therapy system to replace external laser irradiation, primarily composed of d-glucose-based polyoxalate (G-poly(oxalate)), the novel photosensitizer (BD-Se-QM), and bis [2,4,5-trichloro-6-(pentoxy-carbonyl) phenyl] ester. BD-Se-QM possesses excellent singlet oxygen (
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