光热治疗
接受者
共价键
生物相容性
电子受体
光化学
电子供体
纳米技术
化学
材料科学
有机化学
物理
冶金
凝聚态物理
催化作用
作者
Xiuyan Wan,Jie Zhang,Kaiming Zuo,Huiwen Zhang,Hui Hu,Wei Pan,Yanan Gao,Na Li,Bo Tang
标识
DOI:10.1007/s40843-022-2232-4
摘要
A donor-acceptor covalent organic framework (COF), TB-COF, constructed from an electron-rich building unit (donor) and an electron-deficient building unit (acceptor), was developed as a promising photothermal agent for photothermal therapy (PTT). Upon laser irradiation, significant photoinduced electron transfer (PET) occurs between the donor and acceptor in TB-COF, converting the absorbed optical energy to thermal energy and resulting in the ablation of tumor. TB-COF possessed satisfying photothermal conversion efficiency, reaching 43.65%, similar to materials commonly used for PTT. Moreover, hyaluronic acid (HA) was coated on TB-COF to improve its biocompatibility and achieve tumor targeting. Furthermore, in vitro and in vivo experiments confirmed satisfying photothermal anticancer efficacy of TB-COF-HA.
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