嗜睡症
猝倒
精神科
离解的
焦虑
心理学
恐慌
萧条(经济学)
白天过度嗜睡
惊恐障碍
失眠症
医学
临床心理学
儿科
睡眠障碍
莫达非尼
经济
宏观经济学
作者
Valerio Brunetti,Jessica Marotta,Giorgia Simoncini Malucelli,Giuseppe Marano,Marianna Mazza,Giacomo Della Marca
出处
期刊:International Clinical Psychopharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2022-09-15
卷期号:38 (2): 114-116
被引量:3
标识
DOI:10.1097/yic.0000000000000430
摘要
Pitolisant is a histamine 3-receptor antagonist/inverse agonist effective and safe for the treatment of excessive daytime sleepiness and cataplexy in narcolepsy. We report a 19-year-old woman affected by narcolepsy type 1 who presented panic attacks and dissociative symptoms induced by pitolisant. The patient medical history was unremarkable except that for familiarity for anxiety disorder and chronic insomnia. Moreover, a detailed psychometric evaluation revealed a profile of low resilience, a severe grade of depression, an anxiety trait and a propension to dissociative symptoms. Our report suggests that caution should be used in patients with predisposing factors to psychiatric disorders, especially during the first period of treatment with pitolisant. In consideration of the high prevalence of psychiatric comorbidities in narcolepsy, it seems worth to carefully investigate psychiatric background of narcoleptic patients.
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