A Mitochondria‐Targeted Ferroptosis Inducer Activated by Glutathione‐Responsive Imaging and Depletion for Triple Negative Breast Cancer Theranostics

谷胱甘肽 线粒体 三阴性乳腺癌 活性氧 化学 癌细胞 GPX4 癌症研究 程序性细胞死亡 细胞生物学 谷胱甘肽过氧化物酶 细胞凋亡 癌症 生物化学 生物 乳腺癌 遗传学
作者
Hongbo Gan,Xie Huang,Xi Luo,Jinlin Li,Banghui Mo,Lizhi Cheng,Qiuxia Shu,Zaizhi Du,Hong Tang,Wei Sun,Liting Wang,Shenglin Luo,Songtao Yu
出处
期刊:Advanced Healthcare Materials [Wiley]
卷期号:12 (22) 被引量:24
标识
DOI:10.1002/adhm.202300220
摘要

Ferroptosis is a new type of iron-dependent programmed cell death characterized by glutathione (GSH) depletion, selenoprotein glutathione peroxidase 4 (GPX4) inactivation, and lipid peroxides accumulation. Mitochondria, as the main source of intracellular energy supply and reactive oxygen species (ROS) generation, play a central role in oxidative phosphorylation and redox homeostasis. Therefore, targeting cancer-cell mitochondria and attacking redox homeostasis is expected to induce robust ferroptosis-mediated anticancer effects. In this work, a theranostic ferroptosis inducer (IR780-SPhF), which can simultaneously achieve the imaging and therapy of triple-negative breast cancer (TNBC) by targeting mitochondria is presented. It is developed from a mitochondria-targeting small molecule (IR780) with cancer-preferential accumulation, enabling it to react with GSH by nucleophilic substitution, resulting in mitochondrial GSH depletion and redox imbalance. More interestingly, IR780-SPhF exhibits GSH-responsive near-infrared fluorescence emission and photoacoustic imaging characteristics, further facilitating diagnosis and treatment with real-time monitoring of TNBC with a highly elevated GSH level. Both in vitro and in vivo results demonstrate that IR780-SPhF exhibits potent anticancer effect, which is significantly stronger than cyclophosphamide, a classic drug commonly recommended for TNBC patients in clinic. Hence, the reported mitochondria-targeted ferroptosis inducer may represent a promising candidate and a prospective strategy for efficient cancer treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丘比特应助果冻橙采纳,获得10
1秒前
小蘑菇应助魔飞采纳,获得10
2秒前
Cici发布了新的文献求助10
2秒前
2秒前
2秒前
Arueliano完成签到,获得积分10
4秒前
4秒前
AQ完成签到 ,获得积分10
5秒前
霸王龙完成签到,获得积分10
6秒前
Ethan完成签到,获得积分10
6秒前
ererrrr发布了新的文献求助10
9秒前
黎黎完成签到,获得积分10
10秒前
彭于晏应助动听的飞松采纳,获得10
11秒前
开心的曲奇完成签到,获得积分10
11秒前
淡定成风完成签到,获得积分10
11秒前
北开水完成签到,获得积分10
11秒前
娜娜liuna完成签到,获得积分10
14秒前
辣椒小皇纸完成签到 ,获得积分10
15秒前
16秒前
结实智宸完成签到,获得积分10
17秒前
宇心完成签到,获得积分10
17秒前
烟花应助啵清啵采纳,获得10
18秒前
19秒前
yznfly应助清脆的雁丝采纳,获得30
20秒前
21秒前
心随风飞完成签到,获得积分10
21秒前
大模型应助XZZ采纳,获得10
22秒前
zz发布了新的文献求助20
22秒前
填充物完成签到 ,获得积分10
23秒前
小小aa16完成签到,获得积分10
24秒前
24秒前
24秒前
25秒前
25秒前
重生之我的女票是黄毛完成签到,获得积分10
25秒前
今后应助耍酷冬卉采纳,获得10
26秒前
26秒前
GGBoy发布了新的文献求助10
26秒前
26秒前
量子星尘发布了新的文献求助10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970004
求助须知:如何正确求助?哪些是违规求助? 3514701
关于积分的说明 11175468
捐赠科研通 3250051
什么是DOI,文献DOI怎么找? 1795187
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804925