适体
纳米棒
检出限
材料科学
电化学
电极
纳米技术
磁性纳米粒子
超顺磁性
纳米复合材料
线性范围
磁选
再现性
纳米颗粒
化学工程
分析化学(期刊)
化学
色谱法
磁化
磁场
物理
工程类
量子力学
遗传学
物理化学
冶金
生物
作者
Yun Ni,Hezhong Ouyang,Lulu Yu,Ling Chen,Ziye Zhu,Aolin He,Ruijiang Liu
标识
DOI:10.1016/j.bioelechem.2022.108255
摘要
A label-free electrochemical aptasensor based on magnetic α-Fe2O3/Fe3O4 heterogeneous hollow nanorods was developed for the detection of cancer antigen 125 (CA125). Magnetic α-Fe2O3/Fe3O4 heterogeneous hollow nanorods were successfully prepared by the hydrolysis-calcination method, functionalized with polyethyleneimine (PEI), and modified with HAuCl4 to form magnetic α-Fe2O3/Fe3O4-Au nanocomposites with a layer of 5 nm gold nanoparticles (Au NPs) on the surface. The magnetic α-Fe2O3/Fe3O4-Au nanocomposites were used to fix the DNA-aptamer probe to amplify the current signal. The intensity of the current signal was proportional to the concentration of CA125, indicating that the sensor was a turn-on sensor. The linear range of the electrochemical aptasensor was 5-125 U/mL (R2 = 0.9975), and the limit of detection (LOD) was 2.99 U/mL. The electrochemical aptasensor exhibited favorable specificity, reproducibility, and stability. The analytical performance of the aptasensor in real serum samples was also investigated.
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