酶
三元运算
化学
刚度(电磁)
保形涂层
化学工程
材料科学
纳米技术
组合化学
涂层
有机化学
计算机科学
复合材料
工程类
程序设计语言
作者
Guansheng Zheng,Junxian Yang,Liang Zhou,Anna Sinelshchikova,Qi Lei,Jiangguo Lin,Stefan Wuttke,C. Jeffrey Brinker,Zhu Wang
标识
DOI:10.1002/anie.202406110
摘要
The ability to finely tune/balance the structure and rigidity of enzymes to realize both high enzymatic activity and long‐term stability is highly desired but highly challenging. In this work, we propose a new concept of silica‐enzyme, referred to as “silicazyme”, where solid inorganic silica was controlled hybridization with fragile enzyme under moderate condition at single‐enzyme level, realizing simultaneous structure augmentation, long‐term stability, and high enzymatic activity preservation. A multivariate silicification approach was utilized and occurred around individual enzymes to allow conformal coating. To realize a high activity‐stability trade‐off the structure flexibility/rigidity of silicazyme was optimized by a component‐adjustment‐ternary (CAT) plot method. Moreover, the multivariate organosilica frameworks bring great advantages including surface microenvironment adjustability, reversible modification capability, and functional extensibility through the rich chemistry of silica. Overall silicazymes represent a new class of enzymes that promise to broaden their utilization in catalysis, separations, and nanomedicine.
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