外周神经系统
神经系统
水通道蛋白2
神经科学
背根神经节
中枢神经系统
水通道蛋白
外围设备
生物
神经节
水道
三叉神经节
自主神经系统
医学
细胞生物学
内科学
内分泌学
脊髓
机械工程
工程类
入口
心率
感觉系统
血压
作者
Tonghui Ma,Hongwen Gao,Xuedong Fang,Hong Yang
标识
DOI:10.1016/j.mam.2012.03.002
摘要
The expression and function of aquaporins (AQPs) in the peripheral nervous system is a relatively under-investigated subject. Since the original description of AQP1 mRNA expression in the trigeminal ganglion in 2004, there has been significant progress in describing the expression, regulation and function of AQPs in the peripheral nervous system. Three out of the 13 mammalian AQPs (AQP1, AQP2 and AQP4) have been localized to neurons or glial cells in trigeminal ganglia, periodontal Ruffini endings, dorsal root ganglia and the enteric nervous system. Functional studies using knockout mice have suggested the involvement of AQP1 in peripheral pain perception. This review discusses current progress in this field and the possible involvement of AQPs in peripheral neuropathies.
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