线粒体生物发生
生物
PPARGC1A型
辅活化剂
细胞生物学
线粒体
细胞器生物发生
转录因子
DNAJA3公司
生物发生
线粒体DNA
线粒体融合
遗传学
基因
作者
Richard C. Scarpulla,Rick B. Vega,Daniel P. Kelly
标识
DOI:10.1016/j.tem.2012.06.006
摘要
Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation, and other functions. Others govern the expression of nuclear genes required for mitochondrial metabolism and organelle biogenesis. The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family of transcriptional coactivators play a major role in transducing and integrating physiological signals governing metabolism, differentiation, and cell growth to the transcriptional machinery controlling mitochondrial functional capacity. Thus, the PGC-1 coactivators serve as a central component of the transcriptional regulatory circuitry that coordinately controls the energy-generating functions of mitochondria in accordance with the metabolic demands imposed by changing physiological conditions, senescence, and disease.
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