多塔
标签
化学
生长抑素受体
再现性
产量(工程)
高效液相色谱法
生长抑素
奥曲肽
放射化学
色谱法
螯合作用
受体
生物化学
医学
有机化学
材料科学
内科学
冶金
作者
Donato Di Pierro,Anna Rizzello,Gianfranco Cicoria,Filippo Lodi,Mario Marengo,D. Pancaldi,Silvia Trespidi,Stefano Boschi
标识
DOI:10.1016/j.apradiso.2007.12.001
摘要
Somatostatin receptors 1-5 are over expressed in neuroendocrine tumours (NETs). 68Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-Octreotide (DOTA NOC), a recent synthesized somatostatin analogue, shows high affinity for those receptors. Herein, modifications of a commercial module for the labelling of DOTA NOC with 68Ga, as well as the assessment of time course of the radiochemical purity variation are described. The evaluation of radiochemical stability was done by two different chromatographic methods: reversed-phase radio HPLC and fast TLC analysis. Labelled compound has been found radiochemically stable within 3h from the end of labelling (EOL) and radiochemical purity was always higher than 99%. After 73 labelling sessions the system showed great reproducibility and high radiochemical yield.
科研通智能强力驱动
Strongly Powered by AbleSci AI