派尔斑
肠系膜淋巴结
固有层
免疫系统
微熔池
腹膜腔
肠道相关淋巴组织
淋巴
人口
免疫学
生物
化学
病理
医学
解剖
上皮
环境卫生
作者
Micaela Medrano,Silvia Racedo,Ivanna S. Rolny,Analía G. Abraham,Pablo F. Pérez
摘要
The aim of the present study was to evaluate the effect of the oral administration of kefiran on the balance of immune cells in a murine model. Six week old BALB/c mice were treated with kefiran (300 mg/L) for 0, 2 and 7 days. Kefiran treatment increased the number of IgA+ cells in lamina propria after 2 and 7 days. Percentage of B220+/MHCIIhigh cells in mesenteric lymph nodes (2 days) and Peyer's patches (7 days) was higher compared to untreated control mice. An increase of macrophages (F4/80+ cells) was observed in lamina propria and peritoneal cavity (2 and 7 days). In contrast, at day 7, macrophage population decreased in Peyer's patches. These results show the ability of kefiran to modify the balance of immune cells in intestinal mucosa. This property could be highly relevant for the comprehension of the probiotic effect attributed to kefir.
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