Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

An organocatalytic three-component reaction of isatins, malononitrile and isocyanoacetates provided 3,3'-dihydropyrryl-spirooxindoles in excellent yields and enantioselectivities. The products could be readily converted to valuable 3,3'-pyrrolidinyl-spirooxindoles.