The Combination of Glycolic Acid and Hydroquinone or Kojic Acid for the Treatment of Melasma and Related Conditions

黄褐斑 曲酸 乙醇酸 对苯二酚 皮肤病科 PLGA公司 化学 医学 酪氨酸酶 药理学 有机化学 生物化学 乳酸 体外 细菌 生物 遗传学
作者
Alicia Alonso García,James E. Fulton
出处
期刊:Dermatologic Surgery [Ovid Technologies (Wolters Kluwer)]
卷期号:22 (5): 443-447 被引量:148
标识
DOI:10.1111/j.1524-4725.1996.tb00345.x
摘要

Melasma continues to be a difficult problem. Although the cause is genetic, the condition is aggravated with sunlight, birth control pills, and pregnancy. Although hydroquinone is effective and has been available for years, a new product, kojic acid, has the advantage of being pharmaceutically more stable and, also, a tyrosinase inhibitor.To evaluate on melasma and related conditions two similar formulations of glycolic acid/hydroquinone and glycolic acid/kojic acid. The therapeutic index of the two formulations is examined.Thirty-nine patients were treated with kojic acid on one side of the face and hydroquinone in a similar vehicle on the other side of the face. The results were documented by a clinical investigator and with Wood's light examination combined with ultraviolet light photography.Fifty-one percent of the patients responded equally to hydroquinone and kojic acid. Twenty-eight percent had a more dramatic reduction in pigment on the kojic acid side; whereas 21% had a more dramatic improvement with the hydroquinone formulation. These results were not statistically different. The kojic acid preparation was more irritating.Both glycolic acid/kojic acid and glycolic acid/hydroquinone topical skin care products are highly effective in reducing the pigment in melasma patients. Both formulations should be available to the dermatologist to satisfy the patient's preferences.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
2秒前
dzh发布了新的文献求助10
2秒前
czw发布了新的文献求助10
2秒前
123完成签到,获得积分10
2秒前
Owen应助小戴采纳,获得10
3秒前
3秒前
Lam完成签到,获得积分10
5秒前
ww发布了新的文献求助10
6秒前
小余发布了新的文献求助10
6秒前
lyn发布了新的文献求助10
6秒前
zho应助林木森采纳,获得50
7秒前
搜集达人应助立军采纳,获得10
7秒前
小糯米发布了新的文献求助10
8秒前
赘婿应助疲惫的砂糖橘采纳,获得10
8秒前
科研通AI2S应助酷酷雨筠采纳,获得10
9秒前
胡卜卜发布了新的文献求助10
9秒前
11秒前
11秒前
cctv18应助chendumo采纳,获得200
11秒前
段翠完成签到 ,获得积分10
12秒前
12秒前
小二郎应助安详的帽子采纳,获得10
12秒前
13秒前
领导范儿应助Marcus采纳,获得10
14秒前
14秒前
14秒前
Doner完成签到,获得积分10
15秒前
废仙儿发布了新的文献求助30
16秒前
zeed发布了新的文献求助10
17秒前
费小曼发布了新的文献求助10
18秒前
深情安青应助小古采纳,获得10
18秒前
王哪跑12发布了新的文献求助10
18秒前
材料诚完成签到,获得积分10
19秒前
心灵美的安雁完成签到,获得积分20
19秒前
19秒前
20秒前
过儿发布了新的文献求助10
20秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247704
求助须知:如何正确求助?哪些是违规求助? 2890987
关于积分的说明 8265665
捐赠科研通 2559215
什么是DOI,文献DOI怎么找? 1388007
科研通“疑难数据库(出版商)”最低求助积分说明 650670
邀请新用户注册赠送积分活动 627557