2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

In the preceding letter, we described a synthesis of the conserved C.1–C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14–C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1′,3-trisubstituted diene.