登革热
抗药性
生物
灭蚊
埃及伊蚊
疟疾
爆发
伊蚊
载体(分子生物学)
登革热病毒
东南亚
环境卫生
毒理
病毒学
生态学
医学
免疫学
幼虫
古代史
基因
历史
生物化学
重组DNA
作者
Soon Jian Gan,Yong Qi Leong,Muhammad Fakrul Hakim bin Barhanuddin,Siew Tung Wong,Shew Fung Wong,Joon Wah Mak,Rohani Ahmad
标识
DOI:10.1186/s13071-021-04785-4
摘要
Dengue fever is the most important mosquito-borne viral disease in Southeast Asia. Insecticides remain the most effective vector control approach for Aedes mosquitoes. Four main classes of insecticides are widely used for mosquito control: organochlorines, organophosphates, pyrethroids and carbamates. Here, we review the distribution of dengue fever from 2000 to 2020 and its associated mortality in Southeast Asian countries, and we gather evidence on the trend of insecticide resistance and its distribution in these countries since 2000, summarising the mechanisms involved. The prevalence of resistance to these insecticides is increasing in Southeast Asia, and the mechanisms of resistance are reported to be associated with target site mutations, metabolic detoxification, reduced penetration of insecticides via the mosquito cuticle and behavioural changes of mosquitoes. Continuous monitoring of the status of resistance and searching for alternative control measures will be critical for minimising any unpredicted outbreaks and improving public health. This review also provides improved insights into the specific use of insecticides for effective control of mosquitoes in these dengue endemic countries.
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