HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature

A synthesis of α-substituted homoallylamine derivatives is presented, involving the in situ generation of aldimines from readily available aldehydes and 1,1-diphenylhomoallylamines, followed by a 2-aza-Cope rearrangement in HFIP at room temperature.