四环素
强力霉素
拉伤
四环素类抗生素
降级(电信)
生物降解
微生物学
抗生素
化学
盐酸四环素
生物
有机化学
计算机科学
电信
解剖
作者
Hao Tan,Delong Kong,Qing‐Yun Ma,Qingqing Li,Yiqing Zhou,Jianping Xu,Zhiye Wang,Rebecca E. Parales,Zhiyong Ruan
出处
期刊:Microorganisms
[MDPI AG]
日期:2022-03-05
卷期号:10 (3): 565-565
被引量:7
标识
DOI:10.3390/microorganisms10030565
摘要
In this study, the Cutaneotrichosporon dermatis strain M503 was isolated and could efficiently degrade tetracycline, doxycycline, and chlorotetracyline. The characteristics of tetracycline degradation were investigated under a broad range of cultural conditions. Response surface methodology (RSM) predicted that the highest degradation rate of tetracycline could be obtained under the following conditions: 39.69 °C, pH of 8.79, and inoculum dose of 4.0% (v/v, ~3.5 × 106 cells/mL in the medium). In accordance with the five identified degradation products of tetracycline, two putative degradation pathways, which included the shedding of methyl and amino groups, were proposed. Moreover, the well diffusion method showed that the strain of M503 decreases the antibacterial potency of tetracycline, doxycycline, and chlorotetracycline. These findings proposed a putative mechanism of tetracycline degradation by a fungus strain and contributed to the estimation of the fate of tetracycline in the aquatic environment.
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