化学
大戟
立体化学
槲皮素
部分
IC50型
一氧化氮
萜类
消炎药
萜烯
传统医学
有机化学
体外
生物化学
抗氧化剂
药理学
医学
作者
Xue-Long Yan,Bei-Ling Chen,Fang-Yu Yuan,Qihe Zhu,Xu Zhang,Yi Lin,Qing-De Long,Shang‐Gao Liao
标识
DOI:10.1016/j.arabjc.2022.103807
摘要
Six new tigliane diterpenoids, euphkanoids A − F (1–6), along with 12 known diterpenoids (7–18) were isolated from the roots of Euphorbia kansuensis, a traditional Chinese medicinal plant. Their structures were elucidated by spectroscopic analysis, ECD calculation and chemical methods. Compounds 1–3 represent the unusual examples of tigliane diterpenoids with a conjugated olefinic aldehyde moiety. 1–18 and two hydrolyzed analogues (1c and 4a) were screened for the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells. The results showed that 1–3 and 6 markedly inhibited NO production with IC50 values in the range of 4.8–11.3 μM, which were more active than the positive control quercetin (IC50 = 12.3 μM).
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