Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment

Summary The unexpected higher level of IFNγ in a subset of patients with acute myeloid leukemia (AML; IFNγhigh) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFNγhigh cells were not able to induce Tregs alone. See related article by Corradi et al., p. 3141