Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array

Abstract Vertically aligned layered double hydroxide (V‐LDH) array has been growing on various substrates by a simple solution hydrolysis method. The surface shows good topology with LDH edges extending upward, which can potentially rupture the attached bacteria cells and kill them. V‐LDH after calcination shows remarkable enhanced antibacterial properties. Not only do the edges become thinner and sharper, the surface also becomes highly hydrophilic. It is found that surface potential of V‐LDH does not change its antibacterial property. However, the hydrophilicity significantly enhances antibacterial properties. In vitro and in vivo studies demonstrate that the V‐LDH surface has good biocompatibility. The V‐LDH antibacterial coating has potentially broad applications due to its good antibacterial properties and biocompatibility.