糖酵解
厌氧糖酵解
生物
效应器
细胞生物学
细胞功能
功能(生物学)
细胞
生物化学
新陈代谢
遗传学
作者
Chih‐Hao Chang,Jonathan D. Curtis,Leonard B. Maggi,Brandon Faubert,Alejandro V. Villarino,David O’Sullivan,Stanley Ching‐Cheng Huang,Gerritje J. W. van der Windt,Julianna Blagih,Jing Qiu,Jason D. Weber,Edward J. Pearce,Russell G. Jones,Erika L. Pearce
出处
期刊:Cell
[Cell Press]
日期:2013-06-01
卷期号:153 (6): 1239-1251
被引量:1945
标识
DOI:10.1016/j.cell.2013.05.016
摘要
A “switch” from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incompletely understood. We show here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival. When activated T cells are provided with costimulation and growth factors but are blocked from engaging glycolysis, their ability to produce IFN-γ is markedly compromised. This defect is translational and is regulated by the binding of the glycolysis enzyme GAPDH to AU-rich elements within the 3′ UTR of IFN-γ mRNA. GAPDH, by engaging/disengaging glycolysis and through fluctuations in its expression, controls effector cytokine production. Thus, aerobic glycolysis is a metabolically regulated signaling mechanism needed to control cellular function.PaperFlickeyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJhM2I5OTM1ZjBhZWZhYjM1MWY1MDZlZDlkYWVkNzg5YSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc5MTkwOTc1fQ.Rk968c2WBOuzrhkdbM7O8l0YMmSM6DWtCEBl8_Gr6cTQImoR1WcofYMdMe2Z_IzGn0nhT_SNEXWQuf41H-jChxIhXKX0_gypqx9auOj2f45anwLGJfht0iQw1YPjF_7lYQRiFPnyqai592ufqVyjbX43_5womu8j_YMZeCba8mgfmwmh8MbUiVhPkAVJ-fVMb3J2JS514In4JoKcuiqbeRv6GCSbyXDYXAupAZGppbnSTnbHXdCLvpWmmFG4wM9_kPt0GnQL8OY632KdvmPsso3JO5lNNbsQcoRmpki3EDBdPPPpsSQlpc9o-RN9zFHIEkY3tFP7Sh7JExPJYbcVjA(mp4, (70.66 MB) Download video
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