发条
昼夜节律
振荡基因
视交叉上核
时钟
生物钟
细菌昼夜节律
光对昼夜节律的影响
生物
分子钟
神经科学
主时钟
细胞生物学
基因
遗传学
时钟信号
计算机科学
系统发育学
电信
物理
抖动
天文
作者
Steven M. Reppert,David R. Weaver
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2001-03-01
卷期号:63 (1): 647-676
被引量:1357
标识
DOI:10.1146/annurev.physiol.63.1.647
摘要
▪ Abstract In mammals, a master circadian “clock” resides in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. The SCN clock is composed of multiple, single-cell circadian oscillators, which, when synchronized, generate coordinated circadian outputs that regulate overt rhythms. Eight clock genes have been cloned that are involved in interacting transcriptional-/translational-feedback loops that compose the molecular clockwork. The daily light-dark cycle ultimately impinges on the control of two clock genes that reset the core clock mechanism in the SCN. Clock-controlled genes are also generated by the central clock mechanism, but their protein products transduce downstream effects. Peripheral oscillators are controlled by the SCN and provide local control of overt rhythm expression. Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
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