化学
对映选择合成
羟醛反应
环戊烷
卡宾
分子内力
催化作用
试剂
内酯
盐(化学)
有机化学
组合化学
作者
Santigopal Mondal,Subrata Mukherjee,Tamal Das,Rajesh G. Gonnade,Matteo Zanda
标识
DOI:10.1021/acs.joc.7b01526
摘要
N-Heterocyclic carbene (NHC)-catalyzed intramolecular aldol lactonization of readily available ketoacids leading to the enantioselective synthesis of cyclopentane-fused β-lactones is presented. The reaction proceeds via the generation of NHC-bound enolate intermediates formed from the ketoacids in the presence of the peptide coupling reagent HATU and NHC generated from the chiral triazolium salt. The functionalized β-lactones are formed under mild conditions in high yields and enantioselectivities.
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