ESCRT公司
相间
细胞质
核板
细胞生物学
拉明
内膜
核孔
包络线(雷达)
生物
核蛋白
核心
遗传学
基因
内体
细胞内
计算机科学
线粒体
转录因子
电信
雷达
作者
Céline Denais,Rachel M. Gilbert,Philipp Isermann,Alexandra McGregor,Mariska te Lindert,Bettina Weigelin,Patricia M. Davidson,Peter Friedl,Katarina Wolf,Jan Lammerding
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-04-15
卷期号:352 (6283): 353-358
被引量:1056
标识
DOI:10.1126/science.aad7297
摘要
Repairing tears in the nuclear envelope The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab et al. and Denais et al. show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery. Science , this issue pp. 359 and 353 ; see also p. 295
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