磁热疗
氧化铁纳米粒子
化学工程
纳米复合材料
化学
氧化物
药物输送
作者
Ki Hyun Bae,Mihyun Park,Minjae Do,Nohyun Lee,Ji Hyun Ryu,Gun Woo Kim,CheolGi Kim,Tae Gwan Park,Taeghwan Hyeon
出处
期刊:ACS Nano
[American Chemical Society]
日期:2012-05-22
卷期号:6 (6): 5266-5273
被引量:245
摘要
Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.
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