Impact of antibiotic treatment for chronic endometritis on unexplained recurrent pregnancy loss

ABSTRACT Introduction Recurrent Pregnancy Loss (RPL) affects about 1% of all couples and is likely to cause therapeutic vagrancy and psychological distress. Multiple origins can explain RPL, and recent studies suggest the influence of chronic endometritis. The aim of our study is to evaluate the impact of antibiotic treatment on obstetrical prognosis among patients consulting for RPL with isolated chronic endometritis. Material and methods We conducted a monocentric retrospective comparative study. Patients consulting for RPL, with normal etiologic examinations (except for chronic endometritis), were included. In the case of chronic endometritis, patients could receive antibiotic treatment (14 days of doxycycline and metronidazole). Pregnancy outcomes, collected one year after inclusion, were compared between 3 groups: patients without chronic endometritis, patients with treated chronic endometritis, patients with untreated chronic endometritis. Univariate and multivariate analyses were performed. Results 42 patients were included. 22 patients had chronic endometritis. Groups were comparable in terms of age, BMI, the number of miscarriages, tobacco consumption, AMH, and FSH levels on day 2. In multivariate analysis, a significant improvement of live birth rate was observed among patients treated for chronic endometritis, compared to the no endometritis group (OR 21.4 [1.93-236.70] p = 0.013) and the untreated endometritis group (OR 24.90 [1.64-376.93] p = 0.020). Conclusion In our patients examined for RPL, the live birth rate was improved after treatment of chronic endometritis with 14-day antibiotic treatment in comparison to patients with untreated chronic endometritis.