光热治疗
声动力疗法
光动力疗法
纳米技术
费斯特共振能量转移
肿瘤消融
材料科学
体内
光热效应
荧光
化学
烧蚀
医学
光学
有机化学
生物技术
内科学
物理
生物
作者
Bing Wei,F. Dong,Wei Yang,Chunhua Luo,Qiujing Dong,Zuoqin Zhou,Zheng Yang,Liang-Quan Sheng
标识
DOI:10.1016/j.jare.2020.01.011
摘要
For facilitating theranostic nanoplatform with multimodal therapeutic ability, we develop the core-shell structured [email protected]2@TiO2 nanoplatforms (CST NPs). The designed CST NPs possess excellent photothermal effect and fluorescence resonance energy transfer (FRET) induced photodynamic property, which could achieve synergistic photothermal and photodynamic therapy. Meanwhile, the photothermal ability of CST NPs acts as a key role in the application of real-time photothermal imaging, benefitting for the diagnosis of tumor accurately. Moreover, the obtained CST NPs also exhibit outstanding sonodynamic effect with huge potential for sonodynamic therapy. Under the 650 nm laser irradiation, the synthesized CST NPs not only inhibit the growth of cancer cells in vitro, but also display precise photothermal imaging and photo-induced ablation to tumor in vivo. As a result, the prepared CST NPs may potentially serve as multifunctional nanoplatform for theranostic antitumor and pave the avenue for clinic cancer therapy.
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