喜树碱
细胞毒性
化学
细胞培养
立体化学
生物化学
药理学
组合化学
生物
体外
遗传学
作者
Qing Lan,Yiqi Zhou,Xianheng Wang,Yuhe Wang,Changkuo Zhao
标识
DOI:10.1080/14786419.2020.1834546
摘要
In this paper, a series of novel derivatives of camptothecin substituted norcantharimide was designed by mimic strategy. These compounds were synthesized in moderate yields by directly coupling CPT with N-amino acid norcantharimides. Their cytotoxicity to four human tumour cell lines (HepG2, BGC-803, SW480 and PANC-1) and normal human cell lines L-O2 and HIEC was evaluated. The synthesized CPT substituted norcantharimide analogs (3g and 3f) showed better anti-hepatocarcinoma activity than CPT. Compounds 3d, 3e, 3g, 3h and 3i also showed strong inhibition activity against BGC803.
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