Relationship between long non-coding RNA and chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is commonly concerned as a kind of chronic respiratory disease with high morbidity and mortality and heavy medical burden.Oxidative stress, imbalance of protease and anti-protease, and inflammatory reaction are involved in the pathogenetic process of COPD.Long non-coding RNA (lncRNA) is a kind of RNA with more than 200 nucleotides and is unable to be translated to a protein.It can perform its biological function in various ways by acting as a regulation molecule.In recent years, many studies have found that lncRNA plays an important role in the genesis and development of COPD, therefore it may be a target to diagnose and treatment of COPD.This review will summarize and evaluate the progress of study of the relationship between lncRNA and COPD. Key words: Pulmonary disease, chronic obstructive; Immunity; Inflammation; Long non-coding RNA; Glucocorticoid sensitivity