维加维斯
材料科学
聚乙二醇
PEG比率
超顺磁性
生物利用度
化学工程
药物输送
纳米技术
磁场
药理学
磁化
医学
量子力学
物理
工程类
病理
经济
中医药
替代医学
财务
作者
Jingxia Zheng,Chen Bai,Hailong Peng,Zhao Li,Hua Xiong
标识
DOI:10.1016/j.jmmm.2019.166012
摘要
Coix seed oil (CSO) is well-known for wide anti-tumor spectra, but the low bioavailability confined its application. The aim of this study was to prepare nanoscale thermosensitive magnetoliposomes (TML) and identify its possibility to improve the antitumor efficiency of CSO. To obtain TML, polyethylene glycol modified Fe3O4 nanoparticles (PEG-Fe3O4) was prepared by a simple co-precipitation method, PEG-Fe3O4 and CSO were then embed by thermosensitive materials. The results indicated that both TML and PEG-Fe3O4 were superparamagnetic nanoparticles. TML with a phase transition temperature at around 42 °C exhibited temperature sensitive release. In addition, blank TML was nontoxic, while the inhibitory rate of TML containing CSO on HepG2 cells increased significantly when exposed to an external constant magnetic field and preheated treatment. Thus, the fabricated TML has good magnetic targeting effect and fast drug release in response to hyperthermia, which suggests their great potential of application in cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI