焦点粘着
背景(考古学)
细胞生物学
信号转导
细胞粘附
癌细胞
生物
癌症
粘附
癌症研究
细胞
化学
生物化学
遗传学
古生物学
有机化学
作者
Feiyu Chen,Zhangfeng Zhong,Cheng Zhang,Yuanjun Lu,Yau-Tuen Chan,Ning Wang,Di Zhao,Yibin Feng
标识
DOI:10.3390/ijms232113334
摘要
Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularly within the tumor microenvironment. Perturbations in FAK signaling promote tumor occurrence and development, and studies have revealed its biological behavior in tumor cell proliferation, migration, and adhesion. Herein we provide an overview of the complex biology of the FAK family members and their context-dependent nature. Next, with a focus on cancer, we highlight the activities of FAK signaling in different types of cancer and how knowledge of them is being used for screening natural compounds used in herbal medicine to fight tumor development.
科研通智能强力驱动
Strongly Powered by AbleSci AI