微泡
外体
血管生成
翻译(生物学)
计算生物学
生物
小RNA
生物信息学
癌症研究
医学
遗传学
基因
信使核糖核酸
作者
Xue-Ping Zhang,Jun‐Peng Pei,Chun‐Dong Zhang,Maimaititusun Yusupu,Ming-Hao Han,Dong‐Qiu Dai
标识
DOI:10.1016/j.biopha.2022.113921
摘要
Over the last few decades, our understanding of the molecular mechanisms underlying tumor angiogenesis has advanced at a significant pace and the clinical translation of these mechanisms has benefited millions of patients. However, limited efficacy and the rapid expansion of drug resistance remain unresolved issues. Recent studies in both preclinical and clinical settings have revealed that circRNAs, as a novel identified non-coding RNA can mediate intercellular communication and regulate the microenvironment within tumors after being selectively packaged, secreted, and transmitted via exosomes. This review aims to provide a comprehensive understanding of how exosomal circRNAs orchestrate inducers and inhibitors of angiogenesis, including their functions, molecular mechanisms, and potential roles as diagnostic biomarkers and therapeutic targets. Finally, we discuss the technological advances in exosome functionalization and exosome-mimetic nanovesicles intending to improve the clinical translation of exosomal circRNAs.
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