医学
耐火材料(行星科学)
机制(生物学)
糖尿病足
重症监护医学
糖尿病足溃疡
糖基化
糖尿病
内分泌学
生物
天体生物学
认识论
哲学
出处
期刊:PubMed
日期:2022-11-20
卷期号:38 (11): 1085-1089
被引量:2
标识
DOI:10.3760/cma.j.cn501225-20220227-00038
摘要
The number of patients with diabetic foot ulcer (DFU) has increased progressively year by year. Refractory DFU has brought great burden to the country and individuals. How to accelerate the healing of DFU has become the main emphasis of research. However currently, the mechanism of its refractory healing is not fully elucidated, and the correlation between the various mechanisms are not high. Therefore, its clinical standardization, and precise clinical diagnosis and treatment still face several challenges. Based on the progress of clinical research and basic research at home and abroad, this paper reviewed the specific mechanisms that lead to refractory DFU, with the focus on chronic inflammation, bacteria biofilm formation, high oxidative stress, growth factor inhibition, impaired microcirculation, and accumulation of advanced glycation end products.
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