海马结构
记忆巩固
神经科学
海马体
功能磁共振成像
运动学习
心理学
计算机科学
作者
Álvaro Deleglise,Patricio Andres Donnelly‐Kehoe,Abraham Yeffal,Florencia Jacobacci,Jorge Jovicich,Edson Amaro,Jorge L. Armony,Julien Doyon,Valeria Della‐Maggiore
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2022-12-30
卷期号:33 (10): 6120-6131
被引量:4
标识
DOI:10.1093/cercor/bhac489
摘要
Abstract In the last decade, the exclusive role of the hippocampus in human declarative learning has been challenged. Recently, we have shown that gains in performance observed in motor sequence learning (MSL) during the quiet rest periods interleaved with practice are associated with increased hippocampal activity, suggesting a role of this structure in motor memory reactivation. Yet, skill also develops offline as memory stabilizes after training and overnight. To examine whether the hippocampus contributes to motor sequence memory consolidation, here we used a network neuroscience strategy to track its functional connectivity offline 30 min and 24 h post learning using resting-state functional magnetic resonance imaging. Using a graph-analytical approach we found that MSL transiently increased network modularity, reflected in an increment in local information processing at 30 min that returned to baseline at 24 h. Within the same time window, MSL decreased the connectivity of a hippocampal-sensorimotor network, and increased the connectivity of a striatal-premotor network in an antagonistic manner. Finally, a supervised classification identified a low-dimensional pattern of hippocampal connectivity that discriminated between control and MSL data with high accuracy. The fact that changes in hippocampal connectivity were detected shortly after training supports a relevant role of the hippocampus in early stages of motor memory consolidation.
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