Application of Contrast-Enhanced MULTIPLEX T1 and aT1-weighted Imaging in the Diagnosis of Brain Metastases

Motivation: Early monitoring for intracranial metastatic lesions through non-invasive methods will directly impact patient prognosis and quality of life. Goal(s): The aim of this study was to evaluate the performance of MULTIPLEX in detecting brain metastases. Approach: Signal-to-noise ratios (SNRs) for gray matter (GM) and white matter (WM), contrast-to-noise ratios (CNRs) for lesion/GM, lesion/WM, and GM/WM were quantitatively compared. Results: MULTIPLEX aT1 imaging is preferred for depicting lesions containing hemorrhage or calcifications. Impact: The combination of MULTIPLEX T1 and aT1 sequences enhances the detection of brain metastatic lesions compared to T1-GRE imaging, which could be helpful for detecting of small metastatic tumors.