医学
立体定向放射治疗
放射外科
放射治疗
核医学
脑转移
剂量分馏
肿瘤科
内科学
泌尿科
转移
癌症
作者
LEONIE JOHANNWERNER,ELISA M. WERNER,Stefan Janssen,NATHAN Y. YU,Dirk Rades
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2023-05-29
卷期号:43 (6): 2757-2762
被引量:1
标识
DOI:10.21873/anticanres.16443
摘要
Fractionated stereotactic radiotherapy (FSRT) is increasingly used for brain metastases. We investigated higher-dose FSRT with biologically effective doses (BED) of 49.6-66.7 Gy12 Patients and Methods: Eleven characteristics were evaluated for local control (LC), overall survival (OS), and freedom from radiation necrosis (RN) in 69 patients with 1-4 brain metastases. Fifty-seven patients (83%) had extracranial metastases, 23 (33%) Karnofsky performance scores (KPS) ≤70, and 21 (30%) brain metastases ≥21 mm.At 1 and 2 years, LC-rates were 81% and 63%, OS-rates 66% and 43%, and freedom from RN-rates 98% and 87%, respectively. Median time to local progression was 35 months, median survival 19 months. KPS ≥90 was associated with better OS (p=0.048). BED of 49.6-57 Gy12 (vs. 63-66.7 Gy12) was associated with higher rates of freedom from RN (p=0.046), not with LC (p=0.78) or OS (p=0.55).Higher-dose FSRT appears feasible and effective in patients with 1-4 brain metastases. BED 63-66.7 Gy12 may not improve LC and OS but may increase RN risk.
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