光动力疗法
活性氧
谷氨酰胺
谷胱甘肽
体内
化学
肿瘤微环境
癌细胞
烟酰胺腺嘌呤二核苷酸
光敏剂
生物化学
肿瘤缺氧
癌症研究
烟酰胺腺嘌呤二核苷酸磷酸
生物物理学
NAD+激酶
癌症
生物
酶
放射治疗
医学
遗传学
生物技术
有机化学
氨基酸
肿瘤细胞
内科学
氧化酶试验
作者
Zhiyan Li,Xianghui Li,Yanjun Lu,Xudong Zhu,Wenxuan Zheng,Kai Chen,Song Liu,Jinhui Wu,Wenxian Guan
出处
期刊:Small
[Wiley]
日期:2023-10-24
卷期号:20 (10)
被引量:3
标识
DOI:10.1002/smll.202305174
摘要
Abstract Photodynamic therapy (PDT) has promising applications. However, the lethal function of reactive oxygen species (ROS) produced during PDT is typically limited. This restriction is induced by oxygen shortage in the tumor microenvironment due to tumor cell hypermetabolism and reductive chemicals overexpression in tumor tissues. Glutamine (Gln) metabolism is crucial for malignancy development and is closely associated with redox. Herein, a novel nanoparticle (NP) named IRCB@M is constructed to boost PDT through dual effects. This NP simultaneously blocks aerobic respiration and inhibits cellular reduced substances by blocking the Gln metabolic pathway. Within the nanocomplex, a photosensitizer (IR‐780) and a glutaminase inhibitor (CB‐839) are self‐assembled and then encapsulated by cancer cell membranes for homologous targeting. The Gln metabolism intervention relieves hypoxia and decreases the levels of nicotinamide adenine dinucleotide phosphate (NADPH) as well as reduced glutathione (GSH) in vitro and in vivo, which are the dual amplification effects on the IR‐780‐mediated lethal PDT. The antitumor effects against gastric cancer are ultimately evoked in vivo, thus offering a novel concept for enhancing PDT and other ROS‐dependent therapeutic approaches.
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