[Risk modeling based on HER-2 related genes for bladder cancer survival prognosis assessment].

膀胱癌 列线图 肿瘤科 比例危险模型 接收机工作特性 内科学 生存分析 医学 癌症 生物
作者
Huan Rui Liu,Xiang Peng,Sen Lin Li,Xin Gou
出处
期刊:PubMed 卷期号:55 (5): 793-801
链接
标识
摘要

To investigate the correlation between the human epidermal growth factor receptor-2-related genes (HRGs) and survival prognosis of bladder cancer and to construct a predictive model for survival prognosis of bladder cancer patients based on HRGs.HRGs in bladder cancer were found by downloading bladder tumor tissue mRNA sequencing data and clinical data from the cancer genome atlas (TCGA), downloading HER-2 related genes from the molecular signatures database (MsigDB), and crossing the two databases. Further identifying HRGs associated with bladder cancer survival (P < 0.05) by using single and multi-factor Cox regression analysis and constructing HRGs risk score model (HRSM), the bladder cancer patients were categorized into high-risk and low-risk groups accor-ding to the median risk score. Survival analysis of the patients in high- and low-risk groups was conducted using R language and correlation of HRGs with clinical characteristics. A multi-factor Cox regression analysis was used to verify the independent factors affecting the prognosis of the patients with bladder cancer. The area under the curve (AUC) of the receiver operating characteristic curve (ROC) of HRSM was calculated, and a nomogram was constructed for survival prediction of the bladder cancer patients. Analysis of HRSM and patient immune cell infiltration correlation was made using the TIMER database.A total of 13 HRGs associated with patient survival were identified in this study. Five genes (BTC, CDC37, EGF, PTPRR and EREG) were selected for HRSM by multi-factor Cox regression analysis. The 5-year survival rate of the bladder cancer patients in the high-risk group was significantly lower than that of the patients in the low-risk group. High expression of PTPRR was found to be significantly and negatively correlated with tumor grade and stage by clinical correlation analysis, while EREG was found to be the opposite; Increased expression of EGF was associated with high grade, however, the high expression ofCDC37showed the opposite result. And no significant correlation was found between BTC expression and clinical features. Correlation analysis of HRSM with immune cells revealed a positive correlation between risk score and infiltration of dendritic cells, CD8+T cells, CD4+T cells, neutrophils and macrophages.HRGs have an important role in the prognosis of bladder cancer patients and may serve as new predictive biomarkers and potential targets for treatment.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
雄鹰般的女人完成签到,获得积分10
1秒前
优雅的鲂完成签到,获得积分10
2秒前
天天快乐应助木可采纳,获得10
2秒前
2秒前
pywangsmmu92完成签到,获得积分10
2秒前
金鱼驳回了Akim应助
3秒前
3秒前
bckl888发布了新的文献求助10
5秒前
ing关闭了ing文献求助
5秒前
沉默高跟鞋完成签到,获得积分10
6秒前
桐月十六完成签到 ,获得积分10
6秒前
10秒前
10秒前
CharlesL完成签到,获得积分10
12秒前
SciGPT应助lzx采纳,获得10
12秒前
安雯完成签到 ,获得积分10
12秒前
13秒前
13秒前
文静湘完成签到,获得积分10
16秒前
科研通AI2S应助兴奋千兰采纳,获得10
16秒前
17秒前
孙燕应助wang采纳,获得20
17秒前
Katherine完成签到,获得积分10
17秒前
雪白的听寒完成签到 ,获得积分10
18秒前
变式拓展发布了新的文献求助10
19秒前
木可发布了新的文献求助10
19秒前
大个应助帅男采纳,获得10
19秒前
怡然乌完成签到,获得积分10
19秒前
酷炫的幻丝完成签到 ,获得积分10
21秒前
HDM完成签到 ,获得积分10
23秒前
23秒前
luchong发布了新的文献求助10
23秒前
英俊白莲发布了新的文献求助80
30秒前
pp.gsyx完成签到,获得积分10
30秒前
luchong完成签到,获得积分10
30秒前
不是省油的灯完成签到 ,获得积分10
31秒前
sunglow11完成签到,获得积分0
31秒前
愤怒的念烟完成签到,获得积分20
32秒前
dong应助lm采纳,获得10
32秒前
菜芽君完成签到,获得积分10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989589
求助须知:如何正确求助?哪些是违规求助? 3531795
关于积分的说明 11254881
捐赠科研通 3270329
什么是DOI,文献DOI怎么找? 1804966
邀请新用户注册赠送积分活动 882136
科研通“疑难数据库(出版商)”最低求助积分说明 809176