脂质代谢
心脏纤维化
纤维化
重编程
心功能曲线
生物
心肌细胞
细胞生物学
内科学
医学
内分泌学
心力衰竭
心肌细胞
细胞
生物化学
作者
Li-Chan Lin,Zhiyan Liu,Jing‐Jing Yang,Jian‐Yuan Zhao,Hui Tao
标识
DOI:10.1016/j.tem.2023.10.004
摘要
Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal heart performance and act as second messengers to transduce signals within cardiac cells. However, lipid metabolism reprogramming is a double-edged sword in the regulation of cardiomyocyte homeostasis and heart function. Moreover, lipids can exert diverse effects on cardiac fibrosis through different signaling pathways. In this review, we provide a brief overview of aberrant cardiac lipid metabolism and recent progress in pharmacological research targeting lipid metabolism alterations in cardiac fibrosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI