Cytochrome c regulates hyphal morphogenesis by interfering with cAMP-PKA signaling in Candida albicans

mutants remain virulent in mice due to accelerated proliferation. Our results unveil a critical role for cytochrome c in maintaining the virulence of C. albicans by orchestrating proliferation, growth mode, and metabolism. Importantly, this study identifies a biological function for lysine methylation on cytochrome c.