左乙拉西坦
癫痫
卡马西平
显著性(神经科学)
心理学
丙戊酸
医学
全身性癫痫
脑岛
神经科学
作者
Cătălina Elena Bistriceanu,Georgiana-Anca Vulpoi,Iulian Stoleriu,Dan Iulian Cuciureanu
出处
期刊:Biomedicines
[MDPI AG]
日期:2024-07-09
卷期号:12 (7): 1521-1521
标识
DOI:10.3390/biomedicines12071521
摘要
This study aimed to investigate the effects of antiepileptic drugs on salience network regions in patients with epilepsy with generalized tonic-clonic seizures alone (EGTCSa). A retrospective observational case-control study was performed on 40 patients diagnosed with epilepsy with EGTCSa and 40 healthy age-matched controls. In LORETA, a voxel-by-voxel analysis between regions from the salience network was performed for both hemispheres, specifically between the anterior cingulate (BA 32 and BA 24) and the sublobar insula (BA 13). Subsequently, a Wilcoxon rank-sum test (the Mann-Whitney U test) was conducted for the equality of medians in the transformation matrix. A comparison was then made between each region of interest as defined by the salience network and the controls. Marked differences were found in the brain regions assessed in patients with EGTCSa treated with valproic acid and carbamazepine compared to the control group; few differences in patients treated with levetiracetam; and no difference was found in the group without treatment compared with those in the control group. These results suggest that ASMs can influence cognitive processes, which provide novel insights toward understanding the neural mechanisms underlying the effects of ASMs administration.
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