Synthesis of N-alkyl-monosubstituted 1,2,3-triazoles via click reaction using calcium carbide as acetylene source

An effective strategy for constructing mono-substituted 1- benzyl-1H-1,2,3-triazoles was developed via click reactions of benzyl halides with sodium azide and calcium carbide as nitrogen and acetylene sources, respectively. The advantages of this method are easy to handle and inexpensive acetylene sources, a wide range of substrates, satisfactory yields, and simple workup procedures, which can promote the use of calcium carbide as a sustainable acetylene source in modern chemical industry.