线粒体DNA
腺癌
肺
癌症研究
DNA
生物
医学
计算生物学
遗传学
癌症
内科学
基因
作者
Mara Mennuni,Stephen E. Wilkie,P Michon,David Alsina,Roberta Filograna,Markus Lindberg,David E. Sanin,Florian A. Rosenberger,Axel Schaaf,Erik Larsson,Erika L. Pearce,Nils‐Göran Larsson
出处
期刊：Science Advances
[American Association for the Advancement of Science (AAAS)]
日期：2024-11-01
卷期号：10 (44)
标识
DOI：10.1126/sciadv.adp3481
摘要
Lung adenocarcinoma is a common aggressive cancer and a leading cause of mortality worldwide. Here, we report an important in vivo role for mitochondrial DNA (mtDNA) copy number during lung adenocarcinoma progression in the mouse. We found that lung tumors induced by KRAS
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