适体
癌症免疫疗法
免疫疗法
免疫系统
免疫检查点
癌症
计算生物学
癌细胞
癌症研究
生物
化学
免疫学
分子生物学
遗传学
作者
Yihao Huang,Guihong Lin,Sinong Liu,Mingying Chen,Chia‐Ping Huang Yang,Yanling Song
标识
DOI:10.1002/cbic.202400599
摘要
Cancer has long been a significant threat to human life and health. The advent of immune checkpoint blockade strategies has reversed cancer-induced immune suppression, advanced the development of immunotherapy, and offered new hope in the fight against cancer. Aptamers, which possess the same specificity and affinity as antibodies, are advantageous due to their synthetic accessibility and ease of modification, providing novel insights for immune checkpoint research. In this review, we outline the key aptamers currently developed for immune checkpoints such as CTLA-4, PD-1, PD-L1 and Siglec-15. We explore their potential in therapeutic strategies, including functionalizing or engineering aptamers for covalent binding, valency control, and nanostructure assembly, as well as investigating molecular mechanisms such as glycosylated protein functions and cell-cell interactions. Finally, the future applications of aptamers in immunotherapy are discussed.
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