Sonneralignan A, a new lignan from the fruit of mangrove Sonneratia apetala

AbstractA new lignan, sonneralignan A (1), along with two known lignan compounds, (+)-lariciresinol-9-O-β-D-glucopyranoside (2) and (-)isolariciresinol-9-O-β-D-glucopyranoside (3) were isolated from the n-butanol extract of the mangrove Sonneratia apetala fruit. The structures of the compounds were elucidated on the basis of extensive spectral analysis. The evaluation of activity showed that compound 1 exhibited significant anti-aging activity, which extended the mean lifespan of Caenorhabditis elegans by up to 19.13% (p < 0.05) and 55.29% (p < 0.01) under normal and heat stress cultivation conditions, respectively. Molecular docking studies showed that compound 1 was bound to the DNA binding domain of DAF-16 and promoted the conformation of DAF-16, thus strengthening the interaction between the DAF-16 and related DNA. TRP-252, SER-250 and SER-249 of the binding region might be the key amino residues during the interaction.Display full sizeKeywords: Sonneratia apetalachemical compositionanti-aging activity Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work was funded by College Students’ Innovative Entrepreneurial Training Plan Program Guangxi University of Chinese Medicine (grant number S202110600124); Guangxi Key Laboratory of Marine Drugs (grant number 2302603); Guangxi University of Chinese Medicine-Guipai Xinglin Top Talent Funding Project (2022C008); National Science Foundation (grant number U20A20101); Pecial Fund for Bagui Scholars of Guangxi, High-level Talent Inheritance, Innovation Team of Guangxi Traditional Chinese Medicine (grant number 2022A007); Guangxi University of Chinese Medicine "Guipai Traditional Chinese Medicine Inheritance and Innovation Team" Project (grant number 2022B005).