平衡
细胞内
化学
水溶液中的金属离子
金属
纳米技术
生物物理学
材料科学
细胞生物学
生物化学
生物
有机化学
作者
Lihua Xu,Mingzheng Peng,Tingting Gao,Dandan Wang,Xinlei Lian,Huihui Sun,Jinjin Shi,Yafeng Wang,Pengju Wang
标识
DOI:10.1002/advs.202306203
摘要
Abstract Endogenous essential metal ions play an important role in many life processes, especially in tumor development and immune response. The approval of various metallodrugs for tumor therapy brings more attention to the antitumor effect of metal ions. With the deepening understanding of the regulation mechanisms of metal ion homeostasis in vivo, breaking intracellular metal ion homeostasis becomes a new means to inhibit the proliferation of tumor cells and activate antitumor immune response. Diverse nanomedicines with the loading of small molecular ion regulators or metal ions have been developed to disrupt metal ion homeostasis in tumor cells, with higher safety and efficiency than free small molecular ion regulators or metal compounds. This comprehensive review focuses on the latest progress of various intracellular metal ion homeostasis regulation‐based nanomedicines in tumor therapy including calcium ion (Ca 2+ ), ferrous ion (Fe 2+ ), cuprous ion (Cu + ), managanese ion (Mn 2+ ), and zinc ion (Zn 2+ ). The physiological functions and homeostasis regulation processes of ions are summarized to guide the design of metal ion regulation‐based nanomedicines. Then the antitumor mechanisms of various ions‐based nanomedicines and some efficient synergistic therapies are highlighted. Finally, the challenges and future developments of ion regulation‐based antitumor therapy are also discussed, hoping to provide a reference for finding more effective metal ions and synergistic therapies.
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