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Enhancing Spermatogenesis in Non-obstructive Azoospermia through Mesenchymal Stem Cell Therapy

间充质干细胞 无精子症 干细胞 再生(生物学) 精子发生 不育 生殖细胞 男性不育 干细胞疗法 移植 梗阻性无精症 生物 医学 病理 细胞生物学 男科 内科学 遗传学 基因 怀孕
作者
Ria Margiana
出处
期刊:Current stem cell research & therapy [Bentham Science]
卷期号:19
标识
DOI:10.2174/011574888x283311231226081845
摘要

Abstract: Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due to their differentiation potential while maintaining the capability to self-renewal and their unlimited ability to divide and regenerate tissue. A variety of different types of stem cells can be used in cell therapy. Among these, mesenchymal stem cell (MSC) therapy has gradually established itself as a novel method for treating damaged tissues that need restoration and renewal. Male infertility is an important health challenge affecting approximately 8-12% of people around the world. This abnormality can be caused by primary, congenital, acquired, or idiopathic reasons. Men with no sperm in their semen have a condition called azoospermia, caused by non-obstructive (NOA) causes and post-testicular obstructive causes. Accumulating evidence has shown that various types of MSCs can differentiate into germ cells and improve spermatogenesis in the seminiferous tubules of animal models. In addition, recent studies in animal models have exhibited that extracellular vesicles derived from MSCs can stimulate the progression of spermatogenesis and germ cell regeneration in the recipient testes. In spite of the fact that various improvements have been made in the treatment of azoospermia disorder in animal models by MSC or their extracellular vesicles, no clinical trials have been carried out to test their therapeutic effect on the NOA. In this review, we summarize the potential of MSC transplantation for treating infertility caused by NOA.
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