The complex polymer architectures enabled by site-controlled polymerization on nucleic acids

The precision engineering of biohybrid architecture plays a fundamental role in advancing the innovation of downstream biomaterials, yet it is still a huge challenge. In a recent work published in Chem, a serinol-based α-bromoisobutyryl phosphoramidite was reported for site-controlled incorporation into nucleic acid sequences during solid-phase synthesis, which enabled the expansion of the architectural horizon of biohybrids by further integration with atom-transfer radical polymerization. The precision engineering of biohybrid architecture plays a fundamental role in advancing the innovation of downstream biomaterials, yet it is still a huge challenge. In a recent work published in Chem, a serinol-based α-bromoisobutyryl phosphoramidite was reported for site-controlled incorporation into nucleic acid sequences during solid-phase synthesis, which enabled the expansion of the architectural horizon of biohybrids by further integration with atom-transfer radical polymerization.