Isobavachalcone attenuates liver fibrosis via activation of the Nrf2/HO-1 pathway in rats

氧化应激 丙二醛 谷胱甘肽 纤维化 活性氧 超氧化物歧化酶 肝星状细胞 肿瘤坏死因子α 化学 药理学 癌症研究 内科学 医学 生物化学
作者
Xiangshu Wang,Haozhe Tian,Jie Chen,Di Huang,Feng Ding,Tao Ma,Jin Xi,Cheng‐Zhu Wu,Yuxin Zhang
出处
期刊:International Immunopharmacology [Elsevier]
卷期号:128: 111398-111398 被引量:1
标识
DOI:10.1016/j.intimp.2023.111398
摘要

Liver fibrosis, a progression of chronic liver disease, is a significant concern worldwide due to the lack of effective treatment modalities. Recent studies have shown that natural products play a crucial role in preventing and treating liver fibrosis. Isobavachalcone (IBC) is a chalcone compound with anti-inflammatory, antioxidant, and anti-cancer properties. However, its potential antifibrotic effects remain to be elucidated. This study aimed to investigate the antifibrotic effects of IBC on liver fibrosis and its underlying mechanisms in rats. The results showed that IBC significantly ameliorated the pathological damage and collagen deposition in liver tissues; it also reduced the levels of hydroxyproline (HYP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). In addition, IBC activated Nuclear factor E2-associated factor 2/Hemeoxygenase-1 (Nrf2/HO-1) signaling, leading to the nuclear translocation of Nrf2. This translocation subsequently increased the levels of superoxide dismutase (SOD) and glutathione (GSH) and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS), thereby alleviating oxidative stress-induced damage. Moreover, it inhibited the expression of nuclear factor kappa B (NF-κB), which further reduced the levels of downstream inflammatory factors, such as tumor necrosis factor‐alpha (TNF-α), interleukin‐6 (IL-6), and IL‐1 beta (IL-1β), thereby suppressing the activation of HSCs and weakening liver fibrosis. In HSC-T6 cell experiments, changes observed in inflammatory responses, oxidative stress indicators, and protein expression were consistent with the in vivo results. Furthermore, the Nrf2 inhibitor (ML385) attenuated the effect of IBC on inhibiting the activation of quiescent HSCs. Consequently, IBC could alleviate liver fibrosis by activating Nrf2/ HO-1 signaling.
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