Association of Long-Term Exposure to Ambient Fine Particulate Matter with Atherosclerotic Cardiovascular Disease Incidence Varies across Populations with Different Predicted Risks: The China-PAR Project

危险系数 医学 比例危险模型 置信区间 入射(几何) 绝对风险降低 人口 动脉粥样硬化性心血管疾病 微粒 内科学 风险评估 相对风险 人口学 心血管健康 环境卫生 疾病 化学 数学 社会学 有机化学 计算机科学 计算机安全 几何学
作者
Chenxi Yuan,Fangchao Liu,Keyong Huang,Chong Shen,Jianxin Li,Fengchao Liang,Xueli Yang,Jie Cao,Shufeng Chen,Dongsheng Hu,Jianfeng Huang,Yang Liu,Xiangfeng Lu,Dongfeng Gu
出处
期刊:Environmental Science & Technology [American Chemical Society]
卷期号:57 (27): 9934-9942 被引量:7
标识
DOI:10.1021/acs.est.3c01460
摘要

Previous studies have established a significant link between ambient fine particulate matter (PM2.5) exposure and atherosclerotic cardiovascular disease (ASCVD) incidence, but whether this association varies across populations with different predicted ASCVD risks was uncertain previously. We included 109,374 Chinese adults without ASCVD at baseline from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project. We obtained PM2.5 data of participants' residential address from 2000 to 2015 using a satellite-based spatiotemporal model. Participants were classified into low-to-medium and high-risk groups according to the ASCVD 10-year and lifetime risk prediction scores. Hazard ratios (HRs) and 95% confidence intervals (CIs) for PM2.5 exposure-related incident ASCVD, as well as the multiplication and additive interaction, were calculated using stratified Cox proportional hazard models. The additive interaction between risk stratification and PM2.5 exposure was estimated by the synergy index (SI), the attributable proportion due to the interaction (API), and the relative excess risk due to interaction (RERI). Over the follow-up of 833,067 person-years, a total of 4230 incident ASCVD cases were identified. Each 10 μg/m3 increment of PM2.5 concentration was associated with 18% (HR: 1.18; 95% CI: 1.14–1.23) increased risk of ASCVD in the total population, and the association was more pronounced among individuals having a high predicted ASCVD risk than those having a low-to-medium risk, with the HR (95% CI) of 1.24 (1.19–1.30) and 1.11 (1.02–1.20) per 10 μg/m3 increment in PM2.5 concentration, respectively. The RERI, API, and SI were 1.22 (95% CI: 0.62–1.81), 0.22 (95% CI: 0.12–0.32), and 1.37 (95% CI: 1.16–1.63), respectively. Our findings demonstrate a significant synergistic effect on ASCVD between ASCVD risk stratification and PM2.5 exposure and highlight the potential health benefits of reducing PM2.5 exposure in Chinese, especially among those with high ASCVD risk.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
加菲猫发布了新的文献求助10
1秒前
jamin911关注了科研通微信公众号
2秒前
3秒前
like1994发布了新的文献求助10
4秒前
5秒前
shilong.yang发布了新的文献求助20
7秒前
sunny关注了科研通微信公众号
7秒前
包子完成签到,获得积分10
8秒前
8秒前
豆dou发布了新的文献求助10
9秒前
10秒前
请叫我风吹麦浪应助科研采纳,获得10
11秒前
seannnnnnn完成签到 ,获得积分10
12秒前
机灵安白发布了新的文献求助10
12秒前
卡列宁的微笑完成签到,获得积分10
12秒前
李爱国应助Saluzi采纳,获得10
13秒前
15秒前
量子星尘发布了新的文献求助10
15秒前
在水一方应助like1994采纳,获得150
15秒前
15秒前
俏皮蜜蜂发布了新的文献求助10
15秒前
17秒前
半城微凉应助Ethan采纳,获得10
17秒前
nanlinhua完成签到,获得积分10
18秒前
清脆的雁丝完成签到,获得积分10
19秒前
善良的人发布了新的文献求助10
20秒前
周周发布了新的文献求助10
20秒前
科研通AI5应助彼岸花开采纳,获得10
21秒前
沐青应助科研通管家采纳,获得50
22秒前
Jasper应助科研通管家采纳,获得10
22秒前
23秒前
23秒前
hi应助科研通管家采纳,获得10
23秒前
hi应助科研通管家采纳,获得10
23秒前
23秒前
桐桐应助科研通管家采纳,获得10
23秒前
JamesPei应助科研通管家采纳,获得10
23秒前
小马甲应助科研通管家采纳,获得10
23秒前
米尔的猫应助科研通管家采纳,获得20
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970004
求助须知:如何正确求助?哪些是违规求助? 3514701
关于积分的说明 11175468
捐赠科研通 3250051
什么是DOI,文献DOI怎么找? 1795187
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804925